Table 5.

Markers of Platelet Activation and Circulating Microparticles

Measurement	Surface Ligand
Monocyte–platelet conjugate count (primary endpoint)	Events in monocyte gate expressing both leukocyte common antigen (CD45) and a platelet activation marker (CD62P).
Activated platelets	Platelets expressing one or both platelet activation markers P-selectin (CD62P) and CD40 ligand (CD154).
Tissue factor microparticle count	Microparticles expressing tissue factor (CD142).
Platelet microparticle count	Microparticles expressing platelet marker CD42b.
Activated platelet microparticle count	Microparticles expressing both platelet marker (CD42b) and a platelet activation marker (CD62P or CD154).