Table 25.
Ozone Effects on Lung Function, Airway Injury, and Airway Inflammation
| Outcome | Ozone (ppb) | Differences in Effect Estimatesa | 95% CI | Type III SS P Value |
|---|---|---|---|---|
| FEV1 (L)b | 120 | –0.033 | (–0.051 to 0.014) | 0.003 |
| 70 | –0.015 | (–0.033 to –0.004) | ||
| 0 | — | — | ||
| FVC (L)b | 120 | –0.037 | (–0.061 to –0.013) | 0.011 |
| 70 | –0.019 | (–0.043 to 0.005) | ||
| 0 | — | — | ||
| FEV1/FVC (%)b | 120 | –0.134 | (–0.466 to 0.200) | 0.695 |
| 70 | –0.023 | (–0.355 to 0.308) | ||
| 0 | — | — | ||
| FEF25–75 (L/sec)b | 120 | –0.041 | (–0.093 to 0.010) | 0.286 |
| 70 | –0.018 | (–0.069 to 0.033) | ||
| 0 | — | — | ||
| CC16 (ng/mL)c | 120 | 1.98 | (1.06 to 2.90) | <0.001 |
| 70 | 0.69 | (–0.23 to 1.60) | ||
| 0 | — | — | ||
| PMN (% of total)d | 120 | 8.2e | (2.8 to 13.5) | 0.012 |
| 70 | 4.1e | (–1.3 to 9.4) | ||
| 0 | — | — |
a Change from pre- to post-exposure for each ozone concentration, compared to change from pre- to post-exposure at 0 ppb, unless otherwise indicated.
b Measured immediately before the exposure and 15 minutes and 22 hours post-exposure.
c Measured in plasma on the day before exposure and 4 and 22 hours post-exposure.
d Measured in sputum 22 hours post-exposure.
e Single post-exposure measurement, change from 0 ppb.