Commentary Table 2.
Overview of Procedures Performed on the Days Before, During, and After Exposurea
| Procedure | Pre-Exposure Visits | Exposure Visit | Post-Exposure Visit | ||||
|---|---|---|---|---|---|---|---|
| 3 Days Before | 2 Days Before | 1 Day Before | Before Exposure | During Exposure | After Exposure | 1 Day After | |
| Laboratory ozone exposure | X | ||||||
| Personal exposure monitoring (ambient ozone and NO2) | X | X | X | ||||
| Activity diary | X | X | X | ||||
| Physical exam | X | ||||||
| Health questionnaire | X | ||||||
| Symptom questionnaire | X | X | X | X | |||
| Vital signs | X | X | X | X | X | ||
| Electrocardiogram (ECG) | –––––––––Continuous–––––––––– | ||||||
| Brachial artery ultrasound | X | X | |||||
| Blood draw | X | X | |||||
| Spirometry | X | X | X | ||||
| Minute ventilation | X | ||||||
| Sputum induction | X | ||||||
a Three separate sessions were held in which participants were exposed to 0, 70, and 120 ppb ozone (in randomized order) for 3 hours while exercising intermittently (for a total of 9 visits).