Figure 10.

Vagally-induced bronchoconstriction on day 3 in ovalbumin-sensitized (S) and nonsensitized guinea pigs that were treated with etanercept 3 hours before a 4-hour exposure to 2 ppm ozone or filtered air. (A) Nonsensitized: The nonsensitized filtered air and ozone day 3 data from Figure 1, panel A (lines without symbols) are compared to bronchoconstriction on day 3 for guinea pigs treated with etanercept and exposed to either filtered air or ozone. (B) Sensitized: The sensitized filtered air and ozone day 3 data are from Figure 1B (lines without symbols) and are compared to bronchoconstriction on day 3 measured for sensitized guinea pigs treated with etanercept and exposed to either filtered air or ozone. Data are mean ± SEM. Filtered air + etanercept (n = 5), ozone + etanercept (n = 6), sensitized air + etanercept (n = 4), and sensitized ozone + etanercept (n = 4). Brackets show comparisons: * = P < 0.05; # = P < 0.05 by repeated measures two-way ANOVA.