Figure 12.

Newly divided inflammatory cells (BrdU+) on day 3 in BAL for ovalbumin-sensitized (S) guinea pigs that were treated with etanercept 3 hours before a 4-hour exposure to 2 ppm ozone or filtered air. BrdU+ newly divided cells are shown as hatched bars or hatched portions of bars; BrdU– preformed cells are shown as not hatched (white or solid color). Data from animals exposed to filtered air are shown in white bars; data from animals exposed to ozone are in grey bars. The first pair of bars in each column is identical to the day 3 sensitized data in Figure 4; the data are reproduced here to allow statistical comparison. Data are expressed in millions of cells, mean ± SEM. Sensitized filtered air day 3 (n = 8), and sensitized ozone day 3 (n = 8), sensitized filtered air + etanercept (n = 4), sensitized ozone + etanercept (n = 4). Horizontal bars show comparisons: * = P < 0.05 by one-way ANOVA with a Bonferroni correction.