Appendix Figure A.1.

Methacholine-induced bronchoconstriction in ovalbumin-sensitized (S) and nonsensitized guinea pigs exposed to 2 ppm ozone for 4 hours, with or without etanercept (E). (A) Nonsensitized: filtered air (n = 9), ozone day 1 (n = 4), or ozone day 3 (n = 7); (B) Sensitized: filtered air (n = 5) or ozone day 3 (n = 5); (C) Nonsensitized: filtered air + etanercept (n = 5) or ozone day 3 + etanercept (n = 6); (D) Sensitized: filtered air + etanercept (n = 4) or ozone day 3 + etanercept (n = 4). Data are mean ± SEM. * = P < 0.05; # = P < 0.05 by repeated measures two-way ANOVA.