Appendix Figure A.2.

Vagally- or methacholine-induced bradycardia in ovalbumin-sensitized (S) and nonsensitized guinea pigs exposed to 2 ppm ozone for 4 hours, with or without etanercept (E). Panels A–D show vagally-induced bradycardia; Panels W–Z show methacholine-induced bradycardia. (A & W) Nonsensitized: filtered air (n = 9), ozone day 1 (n = 4), or ozone day 3 (n = 7); (B & X) Sensitized: filtered air (n = 5) or ozone day 3 (n = 5); (C & Y) Nonsensitized: filtered air + etanercept (n = 5) or ozone day 3 + etanercept (n = 6); (D & Z) Sensitized: filtered air + etanercept (n = 4) or ozone day 3 + etanercept (n = 4). Data are mean ± SEM. * = P < 0.05; # = P < 0.05 by repeated measures two-way ANOVA.