Table 2.
Summary of Resultsa
| Treatment Group | Exposure / Pretreatment | Vagally Mediated Bronchoconstriction | BrdU+ Eosinophils | ||
|---|---|---|---|---|---|
| Bone Marrow | Blood | BAL | |||
| Nonsensitized | O3 Day 1 | ↑↑↑ | ↑ | – | ↑ |
| O3 Day 3 | ↑↑ | ↑↑ | – | ↑↑ | |
| O3 Day 3 AbIL5 | ↑↑↑↑ | NA | NA | NA | |
| Air + Etanercept | ↑ | – | – | – | |
| O3 Day 3 + Etanercept | ↑↑↑↑ | ↓ | – | ↓ | |
| Sensitized | Air | ↑ | – | – | – |
| O3 Day 3 | ↑↑↑↑ | ↓ | – | ↓ | |
| O3 Day 3 | ↑ | NA | NA | NA | |
| Air + Etanercept | ↑ | – | – | – | |
| O3 Day 3 + Etanercept | ↑↑↑↑ | ↓ | – | – | |
a Results show comparisons with nonsensitized animals breathing filtered air.
NA = not tested. Dash = no change from air-exposed controls. Up arrow = significant increase relative to air-exposed nonsensitized animals. Down arrow = significant decrease relative to air-exposed nonsensitized animals. The number of arrows indicates the size of the effect (not the significance).