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. 2020 May 28;15:3771–3790. doi: 10.2147/IJN.S252223

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© 2020 Chen et al.

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Intra-articular injection of L-rapa at 5 μM and 50 μM in collaboration with LIPUS enhanced type II collagen intensity stained by IHC in the cartilage of knee in spontaneous OA Dunkin-Hartley guinea pigs by approximately 1.8- and 2.8-folds compared to control (I) (Group A: PBS + sLIPUS). IHC intensity of type II collagen was quantified by Image-Pro plus 5.1 and the images were showed at 12.5 magnificence (A-H) (*P<0.05; **P<0.01; ***P<0.001; by one-way ANOVA, Group A: n=5, Groups B~G: n=8, Group H: n=3).