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(A) L-rapa at 5 μM and 50 μM cooperated with LIPUS reduced serum C2C level in spontaneous OA Dunkin-Hartley guinea pigs. (B) Pure rapamycin and L-rapa with or without LIPUS did not significantly affect serum CPX-II level in the guinea pigs (*P<0.05, by one-way ANOVA; Group A: n=5, Groups B~G: n=8, Group H: n=3).
