Table 3.
The Values of Complete Blood Count Were Within the Reference Range47 After Administration with Intra-Articular Injection of Pure Rapamycin or L-Rapa Twice a Week with LIPUS or sLIPUS Thrice a Week, or PBS with LIPUS for 8 Weeks in Spontaneous OA Dunkin-Hartley Guinea Pigs (Group A: n=5, Groups B~G: n=8, Group H: n=3)
| Neutrophil Seg.(%) | Lymphocyte (%) | Monocyte (%) | Eosinophil (%) | Basophil (%) | WBC (103/μL) | RBC (106/μL) | |
|---|---|---|---|---|---|---|---|
| A: PBS + sLIPUS | 48.57 ± 6.59 | 43.76 ± 7.40 | 6.13 ± 1.34 | 1.26 ± 0.09 | 0.26 ± 0.07 | 6.33 ± 0.67 | 5.29 ± 0.10 |
| B: 50 μM Rapamycin + sLIPUS | 56.77 ± 4.74 | 35.75 ± 5.09 | 5.48 ± 0.94 | 1.53 ± 0.24 | 0.47 ± 0.21 | 5.72 ± 0.61 | 5.27 ± 0.07 |
| C: 50 μM L-rapa + sLIPUS | 52.85 ± 1.56 | 38.71 ± 1.80 | 6.78 ± 0.34 | 1.33 ± 0.24 | 0.34 ± 0.10 | 5.24 ± 0.37 | 5.35 ± 0.15 |
| D: 5 μM L-rapa + sLIPUS | 54.24 ± 4.54 | 37.89 ± 4.04 | 6.79 ± 0.69 | 0.74 ± 0.26 | 0.34 ± 0.13 | 5.79 ± 0.46 | 5.31 ± 0.22 |
| E: 50 μM Rapamycin +LIPUS |
46.55 ± 3.25 | 46.76 ± 3.43 | 5.43 ± 0.69 | 0.85 ± 0.17 | 0.41 ± 0.10 | 5.48 ± 0.38 | 5.26 ± 0.25 |
| F: 50 μM L-rapa +LIPUS |
50.46 ± 3.33 | 42.44 ± 3.41 | 5.33 ± 0.33 | 1.43 ± 0.41 | 0.34 ± 0.04 | 6.13 ± 0.91 | 5.41 ± 0.11 |
| G: 5 μM L-rapa +LIPUS |
50.65 ± 3.11 | 42.17 ± 2.92 | 6.12 ± 0.46 | 0.78 ± 0.16 | 0.28 ± 0.08 | 5.27 ± 0.51 | 5.09 ± 0.11 |
| H: PBS +LIPUS |
58.17 ± 2.72 | 34.47 ± 4.09 | 6.23 ± 1.18 | 0.63 ± 0.15 | 0.50 ± 0.25 | 8.07 ± 1.97 | 5.73 ± 0.24 |