Table 2. Top 45 differentially regulated genes (p-value<0.05, fold change >1.5) in dithranol-treated lesional skin after 6 days compared to baseline from 15 patients with psoriasis.
| Probe set ID | Gene symbol | Gene title | Day 6 vs. baseline (fold change) |
|---|---|---|---|
| 16693318 | FLG2 | Filaggrin family member 2 | 2.89 |
| 16693303 | HRNR | Hornerin | 2.64 |
| 16903552 | NEB | Nebulin | 2.18 |
| 16765017 | KRT2 | Keratin 2 | 2.04 |
| 16693308 | FLG | Filaggrin | 1.97 |
| 16761221 | CLEC2A | C-type lectin domain family 2, member A | 1.92 |
| 16730782 | ELMOD1 | ELMO/CED-12 domain containing 1 | 1.91 |
| 16735288 | OVCH2 | Ovochymase 2 | 1.83 |
| 16990787 | SPINK7 | Serine peptidase inhibitor, Kazal type 7 (putative) | 1.78 |
| 16852824 | SERPINB12 | Serpin peptidase inhibitor, clade B (ovalbumin), member 12 | 1.74 |
| 16693341 | LCE1C | Late cornified envelope 1C | 1.71 |
| 16693249 | THEM5 | Thioesterase superfamily member 5 | 1.70 |
| 16921644 | MIRLET7C | MicroRNA let-7c | 1.69 |
| 16670681 | ANXA9 | Annexin A9 | 1.68 |
| 16821186 | CLEC3A | C-type lectin domain family 3, member A | 1.68 |
| 16859090 | CASP14 | Caspase 14 | 1.68 |
| 16765005 | KRT73 | Keratin 73 | 1.66 |
| 16945497 | COL6A5 | Collagen, type VI, alpha 5 | 1.66 |
| 16976615 | SULT1E1 | Sulfotransferase family 1E, estrogen-preferring, member 1 | 1.65 |
| 16898858 | CD207 | CD207 molecule, langerin | 1.63 |
| 16861126 | UPK1A | Uroplakin 1A | 1.60 |
| 16704475 | FAM35DP | Family with sequence similarity 35, member A pseudogene | 1.60 |
| 17085015 | FRMPD1 | FERM and PDZ domain containing 1 | 1.59 |
| 16817034 | CHP2 | Calcineurin-like EF-hand protein 2 | 1.56 |
| 16671082 | LCE1A | Late cornified envelope 1A | 1.55 |
| 16671037 | LCE2D | Late cornified envelope 2D | 1.55 |
| 16748835 | PIK3C2G | Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit | 1.54 |
| 17039517 | LY6G6C | Lymphocyte antigen six complex, locus G6C | 1.53 |
| 16673713 | FMO2 | Flavin containing monooxygenase 2 (non-functional) | 1.52 |
| 16812344 | BCL2A1 | BCL2-related protein A1 | −1.52 |
| 16968213 | ANXA3 | Annexin A3 | −1.54 |
| 17104519 | RNY4P23 | RNA, Ro-associated Y4 pseudogene 23 | −1.55 |
| 16948835 | MIR1224 | MicroRNA 1224 | −1.55 |
| 16815310 | TNFRSF12A | Tumor necrosis factor receptor superfamily, member 12A | −1.60 |
| 17015084 | SERPINB1 | Serpin peptidase inhibitor, clade B (ovalbumin), member 1 | −1.67 |
| 17106398 | SLC6A14 | Solute carrier family 6 (amino acid transporter), member 14 | −1.69 |
| 16693375 | SPRR2F | Small proline-rich protein 2F | −1.69 |
| 17065458 | DEFB4A | Defensin, beta 4A | −1.75 |
| 17074361 | DEFB4B | Defensin, beta 4B | −1.77 |
| 16698947 | RNU5A-8P | RNA, U5A small nuclear 8, pseudogene | −1.78 |
| 16976827 | CXCL5 | Chemokine (C-X-C motif) ligand 5 | −1.81 |
| 16976821 | PPBP | Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | −1.82 |
| 17019056 | TREM1 | Triggering receptor expressed on myeloid cells 1 | −1.99 |
| 17050251 | SLC26A4 | Solute carrier family 26 (anion exchanger), member 4 | −2.19 |
| 16967771 | CXCL8 | Chemokine (C-X-C motif) ligand 8 | −3.36 |