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. 2020 Jun 2;9:e56991. doi: 10.7554/eLife.56991

Table 3. Top 45 differentially regulated genes in dithranol-treated lesional skin at end of treatment compared to baseline from 15 patients with psoriasis (p<0.05, fold change >1.5).

Probe set ID Gene symbol Gene title End of treatment vs. baseline (fold change)
16947045 AADAC Arylacetamide deacetylase 3.07
16765005 KRT73 Keratin 73 2.31
16976868 BTC Betacellulin 2.27
16924792 CLDN8 Claudin 8 2.11
17125092 CNTNAP3 Contactin associated protein-like 3 2.09
17097358 SLC46A2 Solute carrier family 46, member 2 2.07
16780133 SLITRK6 SLIT and NTRK-like family, member 6 2.00
16834436 RAMP2 Receptor (G protein-coupled) activity modifying protein 2 1.96
17123970 ZDHHC11B Zinc finger, DHHC-type containing 11B 1.88
17104313 AR Androgen receptor 1.85
16951140 MIR548I2 MicroRNA 548i-2 1.85
17063366 ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.84
16974224 MIR548I2 MicroRNA 548i-2 1.83
16687914 CYP2J2 Cytochrome P450, family 2, subfamily J, polypeptide 2 1.82
17125106 CNTNAP3B Contactin associated protein-like 3B 1.80
16903552 NEB Nebulin 1.80
17125094 CNTNAP3B Contactin associated protein-like 3B 1.80
16770284 TMEM116 Transmembrane protein 116 1.79
16765041 KRT77 Keratin 77 1.79
17123972 ZDHHC11B Zinc finger, DHHC-type containing 11B 1.78
16688210 MIR3671 MicroRNA 3671 1.78
17125218 CNTNAP3 Contactin associated protein-like 3 1.74
16764923 KRT6A Keratin 6A −3.69
16767261 IL22 Interleukin 22 −3.87
17065453 DEFB103A Defensin, beta 103A −3.94
17074366 DEFB103A Defensin, beta 103A −3.94
16671027 LCE3C Late cornified envelope 3C −4.14
16743751 MMP12 Matrix metallopeptidase 12 (macrophage elastase) −4.42
16979444 TNIP3 TNFAIP3 interacting protein 3 −4.48
17106398 SLC6A14 Solute carrier family 6 (amino acid transporter), member 14 −4.60
16686734 CYP4Z2P Cytochrome P450, family 4, subfamily Z, polypeptide 2 −4.89
16671144 S100A7A S100 calcium binding protein A7A −5.00
16764907 KRT6C Keratin 6C −5.01
16730157 HEPHL1 Hephaestin-like 1 −5.15
16967831 EPGN Epithelial mitogen −5.31
16842517 NOS2 Nitric oxide synthase 2, inducible −5.38
16693409 S100A12 S100 calcium binding protein A12 −6.12
16813112 RHCG Rh family, C glycoprotein −6.18
16738803 TCN1 Transcobalamin I (vitamin B12 binding protein, R binder family) −6.45
16924785 CLDN17 Claudin 17 −8.09
16693365 SPRR2C Small proline-rich protein 2C (pseudogene) −8.72
16967771 CXCL8 Chemokine (C-X-C motif) ligand 8 −9.14
17074361 DEFB4B Defensin, beta 4B −9.39
16693375 SPRR2F Small proline-rich protein 2F −10.12
16884602 IL36A Interleukin 36, alpha −10.50