Table 4. Top 20 significantly enriched pathways as determined by Gene Ontology (GO) enrichment analysis in dithranol-treated lesional skin after 6 days compared to baseline from 15 patients with psoriasis.

(GO was done using Cytoscape software [Bindea et al., 2009; Shannon et al., 2003]; a.o. = among others).

GOID	GO term	P-Value	% Associated Genes	Associated genes found
GO:0001533	Cornified envelope	3.8E-12	10.45	FLG, HRNR, KRT2, LCE1A, LCE1C, LCE2D, SPRR2F
GO:0031424	Keratinization	7.7E-12	3.93	CASP14, FLG, HRNR, KRT2, KRT73, LCE1A, LCE1C, LCE2D, SPRR2F
GO:0030216	Keratinocyte differentiation	79.0E-12	3.02	CASP14, FLG, HRNR, KRT2, KRT73, LCE1A, LCE1C, LCE2D, SPRR2F
GO:0018149	Peptide cross-linking	300.0E-12	9.84	FLG, KRT2, LCE1A, LCE1C, LCE2D, SPRR2F
GO:0070268	Cornification	12.0E-9	5.31	CASP14, FLG, KRT2, KRT73, LCE1A, SPRR2F
GO:0004168	Receptor CXCR2 binds ligands CXCL1 to 7	1.0E-6	33.33	CXCL5, CXCL8, PPBP
GO:0042379	Chemokine receptor binding	5.4E-6	6.25	CXCL5, CXCL8, DEFB4A, PPBP
GO:0045236	CXCR chemokine receptor binding	6.0E-6	18.75	CXCL5, CXCL8, PPBP
GO:0061436	Establishment of skin barrier	18.0E-6	13.04	FLG, FLG2, HRNR
GO:0033561	Regulation of water loss via skin	21.0E-6	12.00	FLG, FLG2, HRNR
GO:0004657	IL-17 signaling pathway	21.0E-6	4.30	CXCL5, CXCL8, DEFB4A, DEFB4B
GO:0007874	Keratin filament formation	21.0E-6	4.17	FLG, KRT2, KRT73, SPRR2F
GO:0030593	Neutrophil chemotaxis	21.0E-6	4.17	CXCL5, CXCL8, PPBP, TREM1
GO:1990266	Neutrophil migration	27.0E-6	3.85	CXCL5, CXCL8, PPBP, TREM1
GO:0071621	Granulocyte chemotaxis	38.0E-6	3.31	CXCL5, CXCL8, PPBP, TREM1
GO:1902622	Regulation of neutrophil migration	45.0E-6	7.50	CXCL5, CXCL8, PPBP
GO:0071622	Regulation of granulocyte chemotaxis	71.0E-6	5.66	CXCL5, CXCL8, PPBP
GO:0030104	Water homeostasis	130.0E-6	4.00	FLG, FLG2, HRNR
GO:0002690	Positive regulation of leukocyte chemotaxis	120.0E-6	3.30	CXCL5, CXCL8, PPBP
GO:0004867	Serine-type endopeptidase inhibitor activity	79.0E-6	3.00	SERPINB1, SERPINB12, SPINK7