Table 7. Top 20 significantly enriched pathways as determined by Gene Ontology (GO) enrichment analysis in dithranol-treated psoriatic skin of c-Jun/JunB knockout mice compared to that of vehicle-treated controls.
(GO was done using Cytoscape software Bindea et al., 2009; Shannon et al., 2003; a.o. = among others).
| Go id | GO term | P-Value | % Associated Genes | Associated genes found |
|---|---|---|---|---|
| GO:0043588 | Skin development | 14,0E-18 | 11,11 | Casp14, Cldn1, Flg2, Gjb3, Hrnr, Ivl, Krt2, Lce1a1, Lce1a2, Lce1l, Lce1m, Lor, Pou2f3, Ptgs1, Scel, Tfap2b, a.o. |
| GO:0008544 | Epidermis development | 73,0E-15 | 9,18 | Acer1, Alox8, Casp14, Cnfn, Cst6, Dnase1l2, Hrnr, Ivl, Krt2, Lce1c, Lce1d, Lce1e, Lce1f, Lce1g, Lce1h, Lce1i, Lce1j, a.o. |
| GO:0071345 | Cellular response to cytokine stimulus | 1,7E-12 | 6,26 | Ccdc3, Ccl2, Ccl5, Ccr9, Cxcl13, Cxcl9, Edn1, Il18, Il1f5, Il1f8, Il1rl1, Il20ra, Stat2, a.o. |
| GO:0034097 | Response to cytokine | 7,1E-12 | 5,62 | Cd38, Chad, Cldn1, Csf3, Edn1, Gbp2, Gbp3, Gbp4, Gbp7, Gbp8, Gbp9, Gm4951, Ifi203, Ifi204, Ifi209, Ifit1, Ifit2, Ifit3, Ifit3b, Xaf1, a.o. |
| GO:0035456 | Response to interferon-beta | 12,0E-12 | 25,00 | Gbp2, Gbp3, Gbp4, Gm4951, Ifi203, Ifi204, Ifi209, Ifit1, Ifit3, Iigp1, Irgm1, Xaf1 |
| GO:0006952 | Defense response | 63,0E-12 | 4,11 | Ccl2, Ccl5, Cd180, Cd59a, Cxcl13, Cxcl9, Cybb, Defb6, Drd1, Herc6, Hp, Il18, Il1f5, Il1f8, Il1rl1, Irgm1, Kalrn, Klk5, a.o. |
| GO:0030855 | Epithelial cell differentiation | 430,0E-12 | 5,51 | Casp14, Cdkn1a, Cldn1, Cnfn, Dlx3, Dnase1l2, Gsdmc2, Gstk1, Hrnr, Ivl, Klf15, Krt2, Lce1a1, Lor, Pou2f3, a.o. |
| GO:0020005 | Symbiont-containing vacuole membrane | 1,4E-9 | 66,67 | Gbp2, Gbp3, Gbp4, Gbp7, Gbp9, Iigp1 |
| GO:0044216 | Other organism cell | 5,6E-9 | 30,77 | C4b, Gbp2, Gbp3, Gbp4, Gbp7, Gbp9, Iigp1, Tap1 |
| GO:0044406 | Adhesion of symbiont to host | 120,0E-9 | 37,50 | Ace2, Gbp2, Gbp3, Gbp4, Gbp7, Gbp9 |
| GO:0045087 | Innate immune response | 390,0E-9 | 4,35 | Ccl2, Ccl5, Cd180, Cfb, Cldn1, Ifit3, Iigp1, Il1f5, Il1f8, Irgm1, Lbp, Ly96, Mx1, Parp9, Sla, Slamf6, Slamf7, Stat2, Tlr7, Trim62, a.o. |
| GO:0034341 | Response to interferon-gamma | 1,0E-6 | 10,58 | Ccl2, Ccl5, Cldn1, Edn1, Gbp2, Gbp3, Gbp4, Gbp7, Gbp8, Gbp9, Parp9 |
| GO:0006954 | Inflammatory response | 5,9E-6 | 4,29 | C3, C4b, Ccl2, Ccl5, Cd180, Cd59a, Chil3, Crip2, Ctla2a, Cxcl13, Cxcl9, Cybb, Hp, Il18, Il1f5, Il1f8, Il1rl1, Lbp, Ly96, a.o. |
| GO:0042832 | Defense response to protozoan | 9,4E-6 | 19,35 | Gbp2, Gbp3, Gbp4, Gbp7, Gbp9, Iigp1 |
| GO:0035457 | Cellular response to interferon-alpha | 21,0E-6 | 36,36 | Ifit1, Ifit2, Ifit3, Ifit3b |
| GO:0030414 | Peptidase inhibitor activity | 22,0E-6 | 6,19 | C3, C4b, Cst6, Ctla2b, Fetub, R3hdml, Serpinb12, Serpinb13, Serpinb2, Serpinb7, Spink14, Tfap2b, Wfdc12, Wfdc5 |
| GO:0098542 | Defense response to other organism | 34,0E-6 | 4,05 | Adm, Ccl5, Cxcl13, Cxcl9, Defb6, Gbp2, Gbp3, Hp, Ifit1, Ifit2, Ifit3, Ifit3b, Iigp1, Il1f5, Klk5, Lbp, Mx1, Oas1f, Plac8, Stat2, Tlr7, Wfdc12, a.o. |
| GO:0031424 | Keratinization | 43,0E-6 | 15,00 | Casp14, Cnfn, Hrnr, Ivl, Krt2, Lor |
| GO:0044403 | Symbiosis, encompassing mutualism through parasitism | 55,0E-6 | 4,11 | Ace2, Acta2, Atg16l2, Ccl5, Cxcl9, Gbp2, Gbp3, Gbp4, Gbp7, Gbp9, Ifit1, Ifit2, Ifit3, Ifit3b, Lbp, Mx1, Oas1f, Pou2f3, Rab9, Stat2, Tap1, Tlr7, Trim62 |