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Comparison of in vivo linezolid levels in the bones of rats treated with different formulations. Rats were injected with free linezolid or linezolid-loaded LPN (both dosed at 20 mg/kg linezolid). After 24 h the tibia were extracted, rinsed, pad-dried and immersed in chloroform to dissolve any nanoparticles in the bones to release linezolid for measurement. The results were normalized (divided by the bone weight) and presented as mean±SD (N=3 per group).
