Table 3.

Multivariate analysis by NCCN testing criteria.

Criterion	BRCA1/2 Testing Criteria Met:	BRCA mutation (n = 12)	No BRCA mutation (n = 187)	Odds Ratio	95% CIa	p value
1	Known family history of BRCA1/2 mutation	2 (16.7%)	2(1.1%)	14.31	1.2–166.3	0.034
2	Age ≤45 at diagnosis	9 (75%)	78 (41.7%)	11.61	1.2–108.6	0.032
3	Age ≤50 and two breast cancer primaries	0 (0%)	11 (5.9%)	–	–	–
4	Age ≤50 with high risk family history	8 (66.7%)	92 (49.2%)	1.12	0.22–5.7	0.89
5	Age ≤60 and TNBC	3 (25%)	28 (14.9%)	1.84	0.37–9.2	0.458
6	Any age with high risk family history	7 (58.3%)	111 (59.4%)	1.25	0.28–5.5	0.769
7	Male breast cancer	0(0%)	1 (0.5%)	–	–	–

^aCI - Confidence Interval.