TABLE 1.
Characteristics of the study participants in the Tennessee Colorectal Polyp Study1
| P for SSL vs. other groups2,3 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | No-polyp controls (n = 3803) | HPs (n = 559) | ADs (n = 1787) | SSLs (n = 212) | P-heterogeneity2 | Controls | HP | AD |
| Age, y | 57.2 (56.9, 57.4) | 56.8 (56.2, 57.4) | 59.0 (58.6, 59.3) | 57.2 (56.7, 58.8) | <0.001 | 0.307 | 0.124 | 0.023 |
| Sex, % F | 44.8 | 36.1 | 28.0 | 36.3 | <0.001 | 0.016 | 0.962 | 0.012 |
| Race, % white | 89.4 | 91.1 | 88.9 | 91.1 | 0.226 | |||
| Study site, % | <0.001 | 0.071 | 0.489 | 0.450 | ||||
| Academic medical center | 74.9 | 66.7 | 66.8 | 69.3 | ||||
| Veterans Affairs medical center | 25.1 | 33.3 | 33.2 | 30.7 | ||||
| Educational attainment, % | <0.001 | 0.056 | 0.548 | 0.555 | ||||
| High school or less | 23.3 | 29.3 | 28.5 | 24.4 | ||||
| Some college | 28.4 | 28.3 | 28.3 | 27.3 | ||||
| College graduate | 21.3 | 21.8 | 22.1 | 27.6 | ||||
| Graduate/professional school | 26.9 | 20.6 | 21.1 | 21.1 | ||||
| Indication for colonoscopy, % | 0.172 | |||||||
| Average risk screening | 57.1 | 54.1 | 55.3 | 57.5 | ||||
| Family history | 12.6 | 13.7 | 12.7 | 16.3 | ||||
| Diagnostic/follow-up | 22.5 | 21.6 | 23.7 | 15.7 | ||||
| Other | 7.8 | 10.5 | 8.3 | 10.5 | ||||
| Family history of colorectal cancer, % | 9.0 | 8.7 | 9.3 | 12.0 | 0.006 | 0.008 | 0.125 | 0.217 |
| Regular alcohol intake, % | 0.016 | 0.130 | 0.958 | 0.360 | ||||
| Never | 59.5 | 53.5 | 56.3 | 53.8 | ||||
| Former | 21.6 | 23.7 | 23.9 | 21.8 | ||||
| Current | 18.8 | 22.8 | 19.8 | 24.4 | ||||
| Cigarette smoking status, % | <0.001 | <0.001 | 0.276 | 0.076 | ||||
| Never | 53.2 | 31.7 | 42.8 | 37.0 | ||||
| Former | 34.2 | 38.1 | 33.3 | 33.2 | ||||
| Current | 12.6 | 30.1 | 23.9 | 29.8 | ||||
| Regular physical activity in the past 10 y, % | 58.3 | 53.2 | 52.3 | 52.6 | <0.001 | 0.184 | 0.942 | 0.700 |
| Current use of NSAIDs, % | 51.7 | 50.9 | 45.7 | 44.7 | <0.001 | 0.007 | 0.066 | 0.204 |
| BMI, kg/m2 | 28.0 | 28.8 | 28.7 | 28.8 | <0.001 | 0.058 | 0.861 | 0.852 |
| Total energy intake, kcal/d | 2048 (2011, 2086) | 2173 (2084, 2261) | 2162 (2108, 2215) | 2031 (1891, 2172) | <0.001 | 0.818 | 0.090 | 0.082 |
1Values are least-square means of log transformed data (lower confidence limit, upper confidence limit) or frequencies standardized to age (5-y categories) and sex distribution of controls, with the exception of age, sex, race, educational attainment, study site, and indication for colonoscopy which are presented as n (%) for categorical data and least-square means (lower confidence limit, upper confidence limit) for continuous data. Statistical significance was set at P < 0.0167. AD, conventional adenoma; HP, hyperplastic polyp; NSAID, nonsteroidal anti-inflammatory drug; SSL, sessile serrated lesion.
2 P values adjusted for age (5-y categories) and sex for all comparisons excluding age, sex, and study site.
3 P values for comparisons of SSL cases vs. controls, HP cases, and AD cases where all P-heterogeneity < 0.05.