TABLE 3.
Median [IQR] percentage relative abundances of sequencing counts representing fecal bacterial genera at 3, 6, 9, and 12 mo of age from either BF, MF, NLB, or SF infants1
Age | Genus | BF | NLB | MF | SF | FDR |
---|---|---|---|---|---|---|
3 | Bifidobacterium | 13.791 [10–33]a | 24.195 [14–35]a | 7.919 [2–12]b | 0.021 | |
3 | f__Clostridiaceae | 0.026 [0–0]a | 0.279 [0–1]b | 0.672 [0–3]b | 0.002 | |
3 | f__Peptostreptococcaceae | 0.053 [0–0]a | 0.219 [0–1]a | 2.225 [1–4]b | <0.001 | |
3 | f__Ruminococcaceae | 0.087 [0–1]a | 0.448 [0–1]b | 2.081 [1–4]c | <0.001 | |
3 | SMB53 | 0.015 [0–0]a | 0.057 [0–0]a | 0.373 [0–1]b | <0.001 | |
6 | Bifidobacterium | 23.625 [15–39]a | 27.52 [12–34]a | 3.361 [0–7]b | <0.001 | |
6 | Coprococcus | 0.021 [0–0]a | 0.293 [0–1]b | 0.481 [0–2]b | <0.001 | |
6 | Enterococcus | 0.044 [0–0]a | 0.04 [0–0]a | 0 [0–0]b | 0.017 | |
6 | f__Clostridiaceae | 0.024 [0–0]a | 0.158 [0–1]ab | 0.571 [0–5]b | 0.007 | |
6 | f__Lachnospiraceae | 0.115 [0–1]a | 0.901 [0–2]b | 4.17 [2–7]c | <0.001 | |
6 | o__Clostridiales | 0 [0–0]a | 0 [0–0]a | 0.226 [0–0]b | <0.001 | |
6 | Roseburia | 0 [0–0]a | 0 [0–0]a | 0.088 [0–2]b | 0.013 | |
6 | SMB53 | 0.007 [0–0]a | 0.071 [0–0]a | 0.616 [0–1]b | <0.001 | |
9 | Akkermansia | 0 [0–0]a | 0.017 [0–0]b | 0.107 [0–2]b | 0.038 | |
9 | Bifidobacterium | 17.951 [11–37]a | 11.847 [10–30]a | 6.065 [3–17]b | 0.038 | |
9 | Clostridium | 1.096 [0–4]a | 0.047 [0–0]b | 0.032 [0–0]b | 0.026 | |
9 | f__Peptostreptococcaceae | 0.064 [0–1]a | 0.282 [0–1]a | 2.447 [1–7]b | 0.005 | |
9 | f__Veillonellaceae | 0.027 [0–2]a | 7.207 [1–18]b | 0 [0–0]a | 0.01 | |
9 | o__Clostridiales | 0 [0–0]a | 0 [0–0]a | 0.228 [0–0]b | <0.001 | |
9 | SMB53 | 0 [0–0]a | 0.076 [0–0]a | 1.227 [1–2]b | <0.001 | |
12 | Bifidobacterium | 14.202 [13–19]a | 8.631 [4–12]ab | 15.18 [6–22]a | 4.604 [2–6]b | 0.008 |
12 | f__Lachnospiraceae | 1.267 [1–2]a | 1.473 [1–3]ab | 2.894 [2–5]bc | 3.836 [2–6]c | 0.012 |
12 | Veillonella | 0.836 [0–4]a | 0.415 [0–1]ab | 0.36 [0–1]ab | 0.25 [0–0]b | 0.047 |
Featured genera were found to be significantly altered by diet by both Kruskal–Wallis and DESeq2 Wald assessments. Zeros indicate abundances of genera lower than the quartiles. See Supplemental Tables 4 and 5 for full assessments of each statistical output. Only the FDRs for the Kruskal–Wallis tests are provided. Groups with different letters differ according to Dunn's test. Sample sizes range from 10 to 20 per diet group at 3, 6, 9, and 12 mo of age. BF, breastfed; FDR, false discovery rate; MF, cow milk–based formula; NLB, no longer breastfeeding; SF, soy-based formula.