TABLE 4.
Abundance of bacterial genera associated with plasma TMAO among 1653 participants in the Adiposity Phenotype Study1
| Phylum; class; order; family; genus | Prevalence | β (SE) | P value | Q value |
|---|---|---|---|---|
| Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae; Prevotella 7 | 0.54 | 0.992 (0.152) | <0.001 | <0.001 |
| Firmicutes; Negativicutes; Selenomonadales; Veillonellaceae; Mitsuokella | 0.23 | 1.444 (0.232) | <0.001 | <0.001 |
| Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae; Prevotella 2 | 0.58 | 0.937 (0.168) | <0.001 | <0.001 |
| Fusobacteria; Fusobacteriia; Fusobacteriales; Fusobacteriaceae; Fusobacterium | 0.53 | 0.931 (0.189) | <0.001 | <0.001 |
| Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae UCG-011 | 0.39 | −0.528 (0.120) | <0.001 | <0.001 |
| Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae NK4A214 group | 0.86 | 0.330 (0.083) | <0.001 | 0.002 |
| Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae; uncultured | 0.27 | 1.196 (0.353) | 0.001 | 0.014 |
| Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; [Ruminococcus] torques group | 1.00 | 0.085 (0.026) | 0.001 | 0.016 |
| Proteobacteria; Deltaroteobacteria; Desulfovibrionales; Desulfovibrionaceae; Bilophila | 0.60 | 0.237 (0.072) | 0.001 | 0.016 |
| Proteobacteria; Deltaroteobacteria; Desulfovibrionales; Desulfovibrionaceae; Desulfovibrio | 0.26 | 0.890 (0.268) | 0.001 | 0.016 |
| Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; [Bacteroides] pectinophilus group | 0.33 | 0.555 (0.174) | 0.001 | 0.018 |
| Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Eisenbergiella | 0.69 | 0.346 (0.114) | 0.002 | 0.028 |
| Proteobacteria; Alpharoteobacteria; Rhodospirillales; uncultured; gut metagenome | 0.56 | 0.455 (0.155) | 0.003 | 0.037 |
1
Parameters derived from the count model from hurdle regression with a negative binomial distribution or standard negative binomial regression, adjusted for age, sex, race-ethnicity, physical activity, percentage body fat, laboratory batch, and total sample sequence count. All taxa with false discovery rate–adjusted Q < 0.05 are included in the table. Prevalence indicates proportion of participants with each genus. TMAO, trimethylamine N-oxide.