Table 1.
Genotype data for select genes in PT+ ABC HSS and ABC tolerant patients.
| Genetic Marker | PT+ ABC HSS N=95 (%) |
Abacavir Tolerant N=43 (%) |
P-value |
|---|---|---|---|
| 57.1 ancestral haplotype markers | |||
| C4A*6 | 79 (83) | 26 (65) | 0.03 |
| Hsp70Hom 493T | |||
| CC | 11 (11.6) | 5 (12.5) | 0.23 |
| CT | 73 (76.8) | 26 (65) | |
| TT | 11 (11.6) | 9 (22.5) | |
| TNF-238 | |||
| AA | 3 (3.2) | 1 (2.5) | 0.76 |
| GA | 85 (89.5) | 38 (95) | |
| GG | 7 (7.37) | 1 (2.5) | |
| TNF-376 | |||
| GA | 1 (1.1) | 1 (2.5) | 0.51 |
| GG | 94 (98.9) | 39 (97.5) | |
| BAT1–223 | |||
| AA | 2 (2.1) | 0 | 0.41 |
| AC | 85 (89.5) | 39 (97.5) | |
| CC | 8 (8.4) | 1 (2.5) | |
| HCP5(rs2395029) | |||
| GG | 2 (2.1) | 0 | 1 |
| GT | 92 (96.8) | 40 (100) | |
| TT | 1 (1.1) | 0 | |
| MICA*017 | 89 (98.9) | 38 (100) | 1 |
| Abacavir Metabolism | |||
| ADH 1C (rs 698) | |||
| AA | 30 (37) | 15 (46.9) | 0.59 |
| GA | 33 (40.7) | 12 (37.5) | |
| GG | 18 (22.2) | 5 (15.6) | |
| ADH 1B (rs 1229984) | |||
| AA | 1 (1.25) | 0 | 1 |
| GA | 10 (12.5) | 4 (12.5) | |
| GG | 69 (86.3) | 28 (87.5) | |
| Innate immune Genes | |||
| CD14 [159 C/T] | |||
| CC | 18 (20.2) | 16 (42.1) | 0.025 |
| CT | 51 (57.3) | 13 (34.2) | |
| TT | 20 (22.5) | 9 (28.1) | |
| KIR3DS1+ | 44 (49.4) | 17 (44.7) | 0.70 |
| KIR3DL1+ | 85 (95.5) | 37 (97.4) | 1 |