Table 1.

Associations between polygenic scores for major depressive disorder (MDD) and loneliness with coronary artery disease (CAD) after excluding patients with a diagnosis of MDD, depressive symptoms, or any psychiatric symptoms

Polygenic score	Patient exclusions	N Cases with CAD	N Controls without CAD	OR (95% CI)	P
MDD	None	3893	4197	1.11 (1.04–1.18)	8.43 × 10−4
MDD	MDD	3744	4037	1.11 (1.05–1.18)	6.54 × 10−4
MDD	Depressive symptoms	2935	3147	1.10 (1.03–1.18)	5.76 × 10−3
MDD	Any psychiatric symptoms	2440	2551	1.11 (1.03–1.19)	9.27 × 10−3
Loneliness	None	3893	4197	1.13 (1.08–1.20)	4.51 × 10−6
Loneliness	MDD	3744	4037	1.13 (1.07–1.20)	9.22 × 10−6
Loneliness	Depressive symptoms	2935	3147	1.14 (1.08–1.22)	2.08 × 10−5
Loneliness	Any psychiatric symptoms	2440	2551	1.12 (1.05–1.20)	8.69 × 10−4

MDD major depressive disorder