Table 3.
Predictors of mortality and poor prognosis (univariate analysis)
| Parameters | Mortality | Poor outcome | ||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| Influenza A | 1.2 (0.3–4) | 0.8 | 3 (1.1–8.8) | 0.02 |
| IAA | 2.2 (0.3–12) | 0.5 | – | < 0.001 |
| Antifungal therapy | 2 (0.5–9) | 0.3 | 32 (4–1451) | < 0.001 |
| Invasive mechanical ventilation | 4.1 (1.1–20) | 0.03 | 17 (5–64) | < 0.001 |
| Vasoactive support | 23 (3.2–1035) | < 0.001 | 20 (6–86) | < 0.001 |
| Renal replacement therapy* | 2 (0.5–8) | 0.3 | 10 (1.9–98) | 0.002 |
| vv-ECMO | 3.6 (0.8–17) | 0.05 | – | < 0.001 |
| Any complication | 5 (1–49) | 0.04 | 3.4 (1.2–11) | 0.02 |
| ARDS | 3 (0.8–11) | 0.1 | 22 (4.6–219) | < 0.001 |
| Respiratory superinfection | 11 (2.7–52) | < 0.001 | 6 (2–19) | < 0.001 |
| Any superinfection** | 6.6 (1.7–32) | 0.002 | 6 (2–18) | < 0.001 |
| Multi-organ failure | – | 0.007 | – | 0.15 |
Significant p values are indicated in italics
*Includes haemodialysis and diafiltration
**Any complication includes ARDS, cardiogenic shock, stroke, multi-organ failure, delirium and other complications
– not applicable due to 0 in the denominator
Vv-ECMO veno-venous extracorporeal membrane oxygenation, ARDS acute respiratory distress syndrome. IAA influenza-associated aspergillosis, OR odds ratio, CI confidence interval