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. 2019 Nov 27;34(6):1658–1668. doi: 10.1038/s41375-019-0662-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — CD90 is overexpressed in a subset of JMML. a Representative flow cytometry plots of a healthy child BM, and patients #92 (NRAS-JMML) and #95 (PTPN11-JMML) with respectively normal and over/ectopic expression of CD90/Thy1 across the different hematopoietic compartments. The first column shows CD90 vs CD45RA within the CD34⁺CD38⁻ fraction, the middle column shows CD135 vs CD45RA and last column shows CD90 vs CD45RA within the CD34⁺CD38⁺ fraction. Gating of cellular HSPC fractions is indicated. b Percentage of CD90/Thy1 expressing cells measured by flow cytometry in JMML compared with healthy children BM within the total CD34⁺CD38⁺ fraction, and across the different hematopoietic progenitor compartments CMP, GMP, MEP (see also Supplementary Table S2). Anova multiple comparison, ****p < 0.0001; ***p < 0.001; ns not significant