Table 2.

Linear regression models investigating the effects of FKBP5 DNA methylation on [A] acute and [B] chronic cortisol release.

A: Dependent variable: cortisol stress response to the Trier Social Stress Test (AUCG).
	β	T	p
Model 1: average FKBP5 DNA methylation
(Constant)	–	1.897	0.059
FKBP5 intron 7 bin 2 methylation	−0.046	−0.748	0.455
Oral contraceptive use	−0.258	−4.179	<0.001
Smoking status	−0.137	−2.239	0.026
Baseline cortisol levels	0.408	6.637	<0.001
Model 2: site-specific FKBP5 DNA methylation
(Constant)	–	0.386	0.700
FKBP5 CpG site 1 methylation	0.056	0.796	0.427
FKBP5 CpG site 2 methylation	−0.095	−1.366	0.173
FKBP5 CpG site 3 methylation	−0.007	−0.105	0.916
Oral contraceptive use	−0.258	−4.057	<0.001
Smoking status	−0.143	−2.298	0.023
Baseline cortisol levels	0.400	6.443	<0.001

B: Dependent variable: hair cortisol concentration (HCC)
Model 3: average FKBP5 DNA methylation
(Constant)	–	0.198	0.843
FKBP5 intron 7 bin 2 methylation	0.041	0.559	0.577
Age	−0.004	−0.049	0.961
Sex	−0.159	−1.547	0.124
Oral contraceptive use	−0.022	−0.242	0.809
Hair treatment	0.010	0.103	0.918
Hair washing frequency	−0.040	−0.522	0.602
Model 4: single CpG site FKBP5 DNA methylation
(Constant)	–	0.753	0.453
FKBP5 CpG site 1 methylation	−0.050	−0.612	0.541
FKBP5 CpG site 2 methylation	0.088	1.048	0.296
FKBP5 CpG site 3 methylation	0.004	0.050	0.960
Age	0.000	0.007	0.995
Sex	−0.140	−1.317	0.189
Oral contraceptive use	−0.029	−0.314	0.754
Hair treatment	0.006	0.062	0.950
Hair washing frequency	−0.035	−0.449	0.654