Table 4.
Top 10 DE metabolites in icm vs donor myocardium.
| Metabolite | Log2 FC | FC | t | P value | Adjusted P value |
|---|---|---|---|---|---|
| Riboflavin-5-monophosphate | −1.11 | −2.20 | −5.72 | 1.01 × 10−06 | 1.27 × 10−04 |
| Cytidine | 1.76 | 3.38 | 4.95 | 1.26 × 10−05 | 5.51 × 10−04 |
| Cytosine | 1.61 | 3.06 | 4.94 | 1.31 × 10−05 | 5.51 × 10−04 |
| Biotin | 0.83 | 1.77 | 4.35 | 8.46 × 10−05 | 2.27 × 10−03 |
| Uridine | 0.82 | 1.77 | 4.32 | 9.50 × 10−05 | 2.27 × 10−03 |
| 2-Deoxycytidine | 1.41 | 2.66 | 4.28 | 1.08 × 10−04 | 2.27 × 10−03 |
| Thyroxine | 0.98 | 1.97 | 3.97 | 2.75 × 10−04 | 4.95 × 10−03 |
| Adenosine | 0.83 | 1.78 | 3.93 | 3.17 × 10−04 | 4.99 × 10−03 |
| Valine | 0.65 | 1.57 | 3.83 | 4.21 × 10−04 | 5.90 × 10−03 |
| Fructose-6-phosphate | −0.73 | −1.67 | −3.63 | 7.65 × 10−04 | 9.64 × 10−03 |
Estimates were derived using the linear regression model adjusted for gender, where nICM = 15 and ndonor = 15; P values were adjusted for multiple comparisons by the Benjamini–Hochberg method. (See Supplementary Data 4).
FC fold change, t t-statistic.