Table 5.

Top 10 DE Metabolites in DCM vs Donor myocardium.

Metabolite	Log2 FC	FC	t	P value	Adjusted P value
Riboflavin-5-monophosphate	−1.27	−2.44	−6.44	9.57 × 10−08	1.21 × 10−05
Kynurenine	0.59	1.51	4.37	8.04 × 10−05	5.06 × 10−03
Fructose-6-phosphate	−0.84	−1.78	−4.08	1.96 × 10−04	8.25 × 10−03
Cystamine	1.17	2.26	3.88	3.64 × 10−04	9.73 × 10−03
Guanidoacetate	0.52	1.43	3.86	3.86 × 10−04	9.73 × 10−03
Ureidopropionic-acid	−0.36	−1.28	−3.72	5.80 × 10−04	1.20 × 10−02
N-Acetyl-l-alanine	−0.33	−1.25	−3.68	6.66 × 10−04	1.20 × 10−02
2-Methylacetoacetate	0.40	1.32	3.51	1.09 × 10−03	1.58 × 10−02
Butyrlcarnitine	−0.21	−1.16	−3.50	1.13 × 10−03	1.58 × 10−02
2-Methylbutyrylcarnitine	−3.33	−10	−3.41	1.44 × 10−03	1.82 × 10−02

Estimates were derived using the linear regression model adjusted for gender, n_DCM = 14 and n_donor = 15; p values were adjusted for multiple comparisons by the Benjamini–Hochberg method. (See Supplementary Data 5).

FC fold change, t t-statistic.