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. 2020 Jun 1;10:177. doi: 10.1038/s41398-020-0853-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–d Representative confocal images of excitatory (red, VGLUT1) and inhibitory (blue, VGAT) puncta in the neuropil of prelimbic cortex of CTRL and DHM animals after administration (VEH or THC). Scale bar: 10 and 3.3 μm for the detail. Graphs representing the density of VGLUT1 (e) and VGAT (f) immunoreactive puncta, and the E/I ratio [number of VGLUT1+ puncta/μm²]/[number of VGAT+ puncta/μm²] (g). e, f graphs show differences in VGLUT and VGAT expression due to THC administration after two-way ANOVA analysis. Horizontal lines in G represent interaction (black, dashed) after two-way ANOVA. Gray symbols and lines in graphs represent statistically significant differences among groups after post hoc. h–k Representative confocal images of excitatory (red, VGLUT1) and inhibitory (blue, VGAT) puncta in the neuropil of Infralimbic cortex of CTRL and DHM animals after administration (VEH or THC). Scale bar: 10 μm and 3.3 μm for the detail. Graphs representing the density of VGLUT1 (l) and VGAT (m) immunoreactive puncta, and the E/I ratio (n). Graphs show differences in the E/I ratio due to the interaction between model and administration after two-way ANOVA analysis p < 0.05 (*), p < 0.01 (**), p < 0.001 (***). Bars represent the mean ± S.E.M. n = 6 animals/group.