Table 4.
Mean trough anti-Xa levels according to renal function
(adapted from Lim et al. [22])
| No.a | Mean (± standard deviation) trough anti-Xa (IU/mL) | P value | ||
|---|---|---|---|---|
| 1st measurement (day 3–5) | 2nd measurement (day 5–7) | |||
| CrCl (mL/min) | ||||
| > 60 | 55/56 | 0.16 (0.11) | 0.15 (0.12) | 0.40 |
| 30–60 | 34/33 | 0.20 (0.17) | 0.17 (0.09) | 0.28 |
| < 30, non-dialysis dependent | 29/26 | 0.29 (0.23) | 0.29 (0.19) | 0.90 |
| 20–29 | 22/19 | 0.25 (0.19) | 0.29 (0.18) | |
| < 20 | 7/7 | 0.41 (0.32) | 0.30 (0.24) | |
| Dialysis-dependent | 26/21 | 0.38 (0.36) | 0.33 (0.20) | 0.61 |
CrCl creatinine clearance, IU international units, Xa factor Xa
aNumber of patients included for 1st measurement/2nd measurement