Table 3.

Eligibility criteria

Inclusion criteria

Exclusion criteria

• Studies including human subjects in good general health (patient/population) • Partially or fully edentulous patients (patient/population) • No restriction on age or gender (patient/population) • Restorations supported by osseointegrated implants with no restriction on material, design, number, location, surgical technique and loading protocol (intervention) • Intervention and comparison group, FISP versus RISP (comparison) • Marginal bone loss around maxillary and mandibular implants, with no restriction on the location (outcome) • Validated, standardized measurement methods to investigate MBL (outcome) • Randomized controlled trials (RCTs), quasi randomized controlled trials (qRCTs), prospective and retrospective studies (study design) • Publications in English or German with no restriction on date (study design)

• Unpublished work • Patients with diabetes, periodontal diseases, pregnancy, osteoporosis, heavy smokers and studies in which >25% of the patient population were smokers • Studies with less than 15 patients • Patients with augmented bone • Tooth-implant-supported restorations • Single-tooth implant restorations • Studies including animals and in vitro studies