Table 2.
Fragmentation Indexes, kRA (Rest-to-Activity) and kAR (Activity-to-Rest) with Incident Heart Failure
| Model | kRA | kAR | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||
| A | + daily activity | 1.26 | (1.06 to 1.48) | 0.01 | 1.07 | (0.80 to 1.35) | 0.60 |
| B | + lifestyle/co-morbidities | 1.24 | (1.04 to 1.48) | 0.01 | 0.88 | (0.61 to 1.26) | 0.48 |
| C | + CVD risk and diseases | 1.21 | (1.02 to 1.46) | 0.03 | 0.89 | (0.61 to 1.31) | 0.56 |
Notes: Cox proportional hazards model of baseline measurements. All models included age, sex and education. Model A: HRs (hazard ratios) for incident HF (heart failure) with total daily activity. Model B was adjusted for depression symptoms, global cognition, antianxiety medication use, insomnia medication use, thyroid disease, alcohol (1 or more drinks per week) and urinary conditions (incontinence/spasms, benign prostatic hypertrophy, diuretic use or associated medications). Model C was further adjusted for smoking, hypertension, cholesterol medication use, diabetes, coronary artery disease and claudication.
Abbreviations: HR, hazard ratio, CI, confidence interval.