Table 4.
Summary of Characteristics (Number of Patients, Additional Statistics Used to Compare Novel Model and Previously Developed Models) of Studies that Used Nomograms
| Nomogram | Han et al27 | Biccler et al28 | Zhong et al26 | Chow et al25 | Go et al29 | Go et al30 | |
|---|---|---|---|---|---|---|---|
| No of pts | 1070 | 5173 | 538 | 76 | 187 | 232 | |
| Test/validation group | 748/322 | 2759/2414 | 228/310 | Internal validation (PFS) | |||
| Additional statistics | c-index=0.77 (5-year) Calibration plot/curve |
c-index=0.756 IBS=0.131 Time-varying AUC |
c-index=0.81 (2-year) Calibration plot/curve |
c-index=0.81 Hosmer and Lemeshow |
c-index=0.80 AIC=599.77–611.77 Calibration plot |
c-index=0.79 | |
| Ratio/difference | NA | NA | NA | NA | NA | NA | |
| Total no of pts in compared index | IPI=748 R-IPI=748 NCCN-IPI=748 |
IPI: NA NCCN-IPI: NA |
IPI=228 NCCN-IPI=228 ICPS=228 Inflammatory IPI=179 |
IPI=76 | IPI=187 R-IPI=187 NCCN-IPI=187 |
IPI=232 R-IPI=232 NCCN-IPI=232 |
|
| 3-year OS (%) per L/H group | L H |
IPI: 78.6/37.8 R-IPI: 91.5/43.5 NCCN-IPI: 85.1/38.7 |
NA | IPI: 92.6/59.2 NCCN-IPI: 93.7/60.1 ICPS: 97.1/66.2 Inflammatory IPI: 95.9/54.7 |
NA | NA | NA |
| Additional statistics | IPI: c-index=0.73 R-IPI: c-index=0.70 NCCN-IPI: c-index=0.71 |
IPI: IBS=0.150 c-index=0.662 NCCN-IPI: IBS=0.144 c-index=0.681 |
IPI: c-index=0.72 NCCN-IPI: c-index=0.72 ICPS: c-index=0.69 Inflammatory IPI: c-index=0.69 |
c-index=0.75 | IPI: −2LL 613.41, AIC 615.41, c-index=0.77 R-IPI: −2LL=630.47; AIC=632.47; c-index=0.74 NCCN-IPI:-2LL 614.18; AIC 616.18; c-index 0.77 |
IPI: c-index=0.74 R-IPI: c-index=0.71 NCCN-IPI: c-index=0.75 |
|
| Ratio | IPI=2.08; R-IPI=2.1; NCCN-IPI=2.2 |
NA | IPI=1.56; Inflammatory IPI=1.75, NCCN-IPI=1.56; ICPS=1.47 | NA | NA | NA | |
| Difference | IPI=40.8; R-IPI=48.0; NCCN-IPI=46.4 |
NA | IPI=33.4; Inflammatory IPI=41.2; NCCN-IPI=33.6; ICPS=1.47 | NA | NA | NA | |
| Difference in c-statistic |
N vs IPI=0.04 N vs R-IPI=0.07 N vs NCCN-IPI=0.06 |
N vs IPI=0.094 N vs NCCN-IPI=0.075 |
N vs IPI=0.09 N vs NCCN-IPI=0.09 N vs Inflammatory IPI=0.12 N vs ICPS=0.12 |
N vs IPI=0.06 | N vs IPI=0.03 N vs R-IPI=0.06 N vs NCCN-IPI=0.03 |
N vs IPI=0.05 N vs R-IPI=0.08 N vs NCCN-IPI=0.04 |
|
Abbreviations: AIC, Akaike’s information criterion; AUC, area under the curve; c-index, concordance index; H, high; IBS, integrated Brier score; ICPS, inflammation-based cumulative prognostic score system; IPI, International Prognostic Index; L, low; 2LL, 2 log likelihood; N, nomogram; NA, not applicable; NCCN-IPI, National Comprehensive Cancer Network-IPI; no, number; OS, overall survival; PFS, progression-free survival; pts, patients; R-IPI, Revised IPI.