Figure 5.

Kaplan-Meier curves for PFS of anti-PD-1 treatment. The difference PFS of anti-PD-1 treatment between high or low group of exosomal PD-L1, exosomal PD-1, co-stimulatory factors and co-inhibitory factors were performed by Kaplan-Meier curves. (A) High CD28, CD80, CD86, GITRL, ICOS, TLR-2, and low exosomal PD-L1 patients showed a prolonged PFS after the anti-PD-1 treatment. The prolonged PFS in the low exosomal PD-1 patients was not statistical. (B) High BTLA and CTLA-4 showed a prolonged PFS. The prolonged PFS in the high LAG-3 patients was not statistical. P-values less than 0.05 was considered that there existed statistical differences. P-values were corrected by FDR (False discovery rate) of Multiple Comparisons Correction.