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. 2020 May 27;8:379. doi: 10.3389/fcell.2020.00379

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Copyright © 2020 Van Der Meulen, Vöcking, Weaver, Meshram and Famulski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Whole Mount In Situ Hybridization (WISH) of known POM and neural crest-related marker genes. Whole-mount in situ hybridization for POM marker gene mRNA expression patterns were observed during early to late stage eye development in the lateral view. POM genes examined were (A) foxc1a, (B) foxc1b, (C) foxd3, (D) pitx2, (E) lmx1b.1, (F) lmx1b.2, (G) sox10, and (H) eya2. Foxc1a, foxc1b, pitx2, eya2, and sox10 in particular show strong expression surrounding the optic cup and on the surface of the anterior segment from 24 to 72 hpf. Lmx1b.1 and lmx1b.2 expression is detected within the anterior segment, surrounding the lens by 48–72 hpf. MHB, midbrain-hindbrain boundary; R, retina; L, lens; OV, optic vesicle; PO, periocular space (outlined with dashed line); OF, optic fissure; AS, anterior segment.