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. 2020 May 27;11:339. doi: 10.3389/fendo.2020.00339

Figure 2.

Figure 2

Schematic representation of eleven preprohormones in Hydra. (A) Preprohormone-A contains unprocessed Hydra-RFamide I, II, III, IV, V, and VI. Preprohormone-B contains unprocessed Hydra-RFamide I, II, V, VII, and VIII. Preprohormone-C contains Hydra-RFamide I and two putative neuropeptide sequences (pQWFSGRFa and pQWLSGRFa). (B) The GLWamide precursor contains unprocessed GLWamides (Hym-53, 54, 248, 249, 331, and 370) and two putative neuropeptide sequences (Hydra-LWamide VI and VIII). (C) The Hym-176 precursor (Hym-176A) contains one copy of unprocessed Hym-176 and Hym-357. Hym-176B contains Hym-357 and one putative neuropeptide (KPLKVMKM). Hym-176C and Hym-176D contain one copy of Hm-176-homologous peptide (Hym-176C and Hym-176D), respectively. Hym-176C also contains one unprocessed Hym-690. Hym-176E contains one putative neuropeptide sequence (NPFIFKGHKH). (D) The Hym-355 precursor contains one unprocessed Hym-355. (E) The FRamide precursor contains unprocessed FRamide-1 and−2. Black box: signal sequence, a: amide.