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. 2020 May 27;11:347. doi: 10.3389/fendo.2020.00347

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Copyright © 2020 Cruz-Topete, Oakley and Cidlowski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Physiological glucocorticoid effects. Glucocorticoids exert direct actions in major organ systems of the human body. Their effects range from modulation of the inflammatory and immune response to the regulation of glucose and lipid metabolism in different tissues. Glucocorticoid signaling plays an essential role on the cardiovascular system. In normal physiology, glucocorticoids exert cardioprotective and anti-inflammatory effects, and have an essential role in controlling blood pressure and cardiac function.