Table 1.
Clinical studies assessing TB sequelae.
| References | Study site | Study type and design post-treatment commencement | ATB sample size, n | Nature of residual lung impairment | Associated inflammatory response |
|---|---|---|---|---|---|
| Ngahane et al. (46) | Cameroon | Cross-sectional Includes HIV+ | 269 | Structural (CXR lesions) and Functional (dyspnoea and spirometry) | No |
| Ralph et al. (13) | Indonesia | Longitudinal [Baseline (BL), 6M & over 6M] Includes HIV+ | 200 | Structural (CXR score of lesions and cavitation) and Functional (dyspnoea, SGRQ, spirometry) | No |
| Kumar et al. (47) | India | Longitudinal (BL & 6M) No HIV+ cases Part of larger study involving patients with co-morbidities | 24 | Structural (cavitation; no CXR-score) | Yes |
| Ravimohan et al. (48) | USA | Prospective (over 6M) All TB/HIV+ | 14 | Functional (spirometry) | Yes (MMPs) |
| Pasipanodya et al. (11) | USA | Longitudinal (BL, 6M & over 6M) Includes HIV+ | 177 | Functional (SGRQ and spirometry) | No |
| Plit et al. (42) | South Africa | Longitudinal (BL & 6M) Includes HIV+ | 76 | Structural (CXR score of lung infiltrates) Functional (spirometry) | Yes (c-reactive protein (CRP) and serum α1-protease inhibitor (α1-PI) |
| Cole et al. (43) | South Africa | Cross-sectional Includes HIV+ | 55 | Functional (SGRQ and spirometry) | No |
| Patil and Patil (44) | India | Longitudinal (6M, 9M, & 12M) No HIV+ cases | 118 | Functional (dyspnoea and spirometry) | No |
| Hnizdo et al. (4) | South Africa | Retrospective (BL-−375M) Includes HIV+ | 2,599 | Functional (spirometry) | No |
| Maguire et al. (45) | Indonesia | Longitudinal (BL, 2M, & 6M) Includes HIV+ | 115 | Functional (dyspnoea, SGRQ, spirometry) | No |
| Saldana et al. (41) | Mexico | Cross-sectional Includes HIV+ | 127 | Functional (Spirometry) and Structural (CXR abnormalities) | No |
| Vecino et al. (14) | USA | Longitudinal (BL, 6M, & over 6M) | 123 | Functional (Spirometry) | No |
| Chushkin et al. (3) | Russia | Prospective (Over 12M) Undetermined HIV status | 214 | Functional (Spirometry) | No |