Table 5.
Imprecision [relative root mean square error (rRMSE)] in individually predicted doses at the next occasion, taking information from one (day 1), two (day 1, 7), or three (day 1, 7, 14) sampling occasions using three samples (pre-dose, and 2 and 4 h post-dose) per occasion into account for Empirical Bayes Estimates (EBE) estimation.
| True dose | rRMSE (%) | ΔrRMSE (%) | rRMSE (%) | ΔrRMSE (%) | rRMSE (%) | N |
|---|---|---|---|---|---|---|
| One occasion | (One/two occasions) | Two occasions | (Two/three occasions) | Three occasions | ||
| (95% CI) | (95% CI) | |||||
| All doses | 19.3 | [−0.10 to −0.08]* | 10.2 | [0.00 to 0.00] | 10.1 | 1,000 |
| 600 | 50.0 | – | 0.0 | – | 0.0 | 1 |
| 900 | 53.3 | [−0.57 to −0.30]* | 9.9 | [0.00 to 0.03] | 11.4 | 34 |
| 1,200 | 27.8 | [−0.20 to −0.15]* | 10.2 | [0.00 to 0.01] | 10.8 | 133 |
| 1,500 | 15.9 | [−0.06 to −0.05]* | 10.5 | [0.00 to 0.00] | 10.5 | 325 |
| 1,800 | 10.5 | [−0.03 to −0.02]* | 8.3 | [0.00 to 0.00] | 8.5 | 292 |
| 2,100 | 14.8 | [−0.05 to −0.03]* | 10.9 | [−0.01 to 0.00] | 10.3 | 162 |
| 2,400 | 20.0 | [−0.07 to −0.04]* | 14.6 | [−0.04 to −0.02]* | 11.4 | 47 |
| 2,700 | 24.4 | [−0.14 to −0.04]* | 15.7 | [0.00 to 0.00] | 15.7 | 6 |
rRMSE, relative root mean square error; CI, confidence interval.
*Statistically significant difference (p-value < 0.05) in rRMSE between taking information from one or two occasions, or between taking two or three occasions, into account to predict individual doses at the next occasion.