Table 6.
Bias [mean absolute percentage error (MAPE)] in individually predicted doses at the next occasion, taking information from one (day 1), two (day 1, 7) or three (day 1, 7, 14) sampling occasions using three samples (pre-dose, and 2 and 4 h post-dose) per occasion into account for Empirical Bayes Estimates (EBE) estimation.
| True dose | MAPE (%) | ΔMAPE (%) | MAPE (%) | ΔMAPE (%) | MAPE (%) | N |
|---|---|---|---|---|---|---|
| One occasion | (One/two occasions) | Two occasions | (Two/three occasions) | Three occasions | ||
| (95% CI) | (95% CI) | |||||
| All doses | 13.3 | [−0.09 to −0.07]* | 5.6 | [−0.01 to 0.00] | 5.5 | 1,000 |
| 600 | 50.0 | – | 0.0 | – | 0.0 | 1 |
| 900 | 46.1 | [−0.53 to −0.33]* | 2.9 | [−0.02 to 0.04] | 3.9 | 34 |
| 1200 | 21.1 | [−0.20 to −0.14]* | 4.1 | [−0.0 to 0.02] | 4.7 | 133 |
| 1,500 | 11.9 | [−0.08 to −0.05]* | 5.5 | [−0.01 to 0.01] | 5.5 | 325 |
| 1,800 | 6.5 | [−0.03 to −0.01]* | 4.1 | [0.00 to 0.01] | 4.3 | 292 |
| 2100 | 12.6 | [−0.06 to −0.04]* | 7.8 | [−0.02 to 0.00] | 7.1 | 162 |
| 2400 | 18.6 | [−0.08 to −0.04]* | 12.8 | [−0.05 to −0.02]* | 9.3 | 47 |
| 2700 | 24.1 | [−0.13 to −0.06]* | 14.8 | [0.00 to 0.00] | 14.8 | 6 |
MAPE, mean absolute percentage error; CI, confidence interval.
*Statistically significant difference (p-value < 0.05) in MAPE between taking information from one or two occasions, or between taking two or three occasions, into account to predict individual doses at the next occasion.