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. 2020 May 27;11:890. doi: 10.3389/fimmu.2020.00890

Figure 2.

Figure 2

Overexpression of miR-128 inhibited tumor growth and metastasis in PDAC. To establish the orthotopic mouse model of PDAC, miR-NC/miR-128 stable overexpression Panc02 cells were directly injected into the pancreas of C57BL/6 mice (n = 5/group). (A) A schematic diagram of the mouse model of PDAC. (B) Typical tumor photograph. (C) Tumor volume. (D) Tumor weight. (E) Macroscopic image of liver metastasis. The red arrows point to the metastatic sites. (F) Hematoxylin and eosin (HE) staining of liver metastasis; the areas of metastasis were circled in red. (G) The statistics of liver metastasis. The results represent the mean ± SEM from three independent experiments. Comparisons between groups were determined by Student's t-test. *p < 0.05, **p < 0.01.