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. 2020 May 27;8:271. doi: 10.3389/fped.2020.00271

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Copyright © 2020 Zhang, Chu, Weng, Gong and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RAC of lung tissue in two groups at different time points. From the center of respiratory bronchioles to the nearest pleura or fibrous septum, a vertical line is drawn. The number of alveoli on this line is the RAC, which reflects the development of alveoli. Compare with the air group, the RAC of hyperoxia group was significantly lower than that of the air group (p < 0.05). The RAC of the air group increased while the hyperoxia group decreased gradually after 7 days. ^***p < 0.001.