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. 2020 May 27;10:838. doi: 10.3389/fonc.2020.00838

Table 1.

Characteristics of the training and validation cohorts.

Characteristics Training set (n = 84) Validation set (n = 37)
AIS/MIA (n = 25) IA (n = 59) P AIS/MIA (n = 11) IA (n = 26) P
Gender
Female 16 (64.00%) 43 (72.88%) 0.416 9 (81.82%) 19 (73.08%) 0.695
Male 9 (36.00%) 16 (27.12%) 2 (18.18%) 7 (26.92%)
Age (year) 52.44 ± 12.71 60.22 ± 10.24 0.004 52.73 ± 11.23 56.96 ± 10.63 0.283
Location 0.546 0.289
Right upper lobe 13 (52.00%) 22 (37.29%) 7 (63.64%) 9 (34.62%)
Right middle lobe 1 (4.00%) 6 (10.17%) 0 (0.00%) 4 (15.38%)
Right lower lobe 3 (12.00%) 7 (11.86%) 3 (27.27%) 4 (15.38%)
Left upper lobe 6 (24.00%) 12 (20.34%) 1 (9.09%) 6 (23.08%)
Left lower lobe 2 (8.00%) 12 (20.34%) 0 (0.00%) 3 (11.54%)
Spiculation 0.001 0.014
Absent 20 (80.00%) 23 (38.98%) 10 (90.91%) 12 (46.15%)
Present 5 (20.00%) 36 (61.02%) 1 (9.09%) 14 (53.85%)
Lobulation 0.003 0.719
Absent 16 (64.00%) 17 (28.81%) 6 (54.55%) 11 (42.31%)
Present 9 (36.00%) 42 (71.19%) 5 (45.45%) 15 (57.69%)
Pleural Indentation 0.129 0.141
Absent 18 (72.00%) 32 (54.24%) 9 (81.82%) 13 (50.00%)
Present 7 (28.00%) 27 (45.76%) 2 (18.18%) 13 (50.00%)
Air Bronchogram 0.651 0.015
Absent 19 (76.00%) 42 (71.19%) 11 (100.00%) 15 (57.69%)
Present 6 (24.00%) 17 (28.81%) 0 (0.00%) 11 (42.31%)
Vacuole 0.923 0.083
Absent 22 (88.00%) 54 (91.53%) 9 (81.82%) 26 (100.00%)
Present 3 (12.00%) 5 (8.47%) 2 (18.18%) 0 (0.00%)
Vessel Convergence 0.034 0.091
Absent 9 (36.00%) 9 (15.25%) 5 (45.45%) 4 (15.38%)
Present 16 (64.00%) 50 (84.75%) 6 (54.55%) 22 (84.62%)
Nodule Type 0.309 0.699
Pure GGN 10 (40.00%) 11 (18.64%) 4 (36.36%) 7 (26.92%)
Part-solid GGN 15 (60.00%) 48 (81.36%) 7 (63.64%) 19 (73.08%)
Diameter 11.72 ± 6.13 14.81 ± 5.86 0.032 9.36 ± 4.11 14.62 ± 4.88 0.004

AIS, adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; IA, invasive adenocarcinoma; GGN, ground-glass nodule.