Figure 1.
Anti-tumor effects induced by different immunization. (A) Mice (n = 3 per group) were inoculated (s.c.) with 1 × 106 TC-1 cells and vaccinated (i.v.) 6 days later with PBS, HPV16 E7 peptide alone, peptide plus polyIC, peptide and polyIC plus αCD40 mAb. (B) In the preventive model, nude mice after 2.4 Gy radiation were injected with 10 million of total splenocytes of the immunized mice when TC-1 tumor appeared. Tumor growth was measured (two opposing diameters) and recorded once every 3 days. Data shown represent three independent experiments with similar results. *p < 0.05, **p < 0.01, ***p < 0.001, n.s, p > 0.05.