Table 1.

Current WHO grading guidelines and 8th AJCC/UICC—ENETS consensus for pancreatic neuroendocrine neoplasms (11, 12).

WHO, World Health Organization; NEN, Neuroendocrine Neoplasm; NET/C, Neuroendocrine Tumour/Carcinoma; HPF, Hight Power Field; AJCC, American Joint Committee on Cancer; ENETS, European Neuroendocrine Tumour Society; UICC, Union for International Cancer Control; ADC, Adenocarcinoma; SCC, Squamous cell Carcinoma. ^∙Neoplastic evolution Current classification considers the possibility of an evolution with time of a well-differentiated G1-G2 NEN to a higher G3 and, even more rarely, toward a poorly differentiated NEC (13). **MiNENs (Mixed-NENs): may contain of non- neuroendocrine components (e.g., adeno or squamous) and neuroendocrine ones (at least 30% for each component) (11). *Specific parameters for PanNET according to 8th AJCC/UICC-ENETS consensus.