Table 1.
Technical features of NGF and NGS for MRD detection.
NGF | NGS | |
---|---|---|
Applicability (% cases) | 99% | ~90% |
Sensitivity | 2–4 × 10−6 | 10−6 |
Time to result | 2–3 h | ≥7days |
Number of cells required | 2 × 107 | 2–3 × 106 |
Need for fresh sample | Yes (within 24 h) | No |
Need for diagnostic sample | No | Yes |
Quantitative | Yes | Yes |
Intrinsic quality control for hemodilution | Yes | No |
Cell characterization | Yes | No |
Molecular characterization | No | Yes |
Availability | Wide | Limited |
Reproducibility among centers | High | Not reported |
Harmonization | Yes | Not reported |
Cost | + | ++ |