Table 1.
Technical features of NGF and NGS for MRD detection.
| NGF | NGS | |
|---|---|---|
| Applicability (% cases) | 99% | ~90% |
| Sensitivity | 2–4 × 10−6 | 10−6 |
| Time to result | 2–3 h | ≥7days |
| Number of cells required | 2 × 107 | 2–3 × 106 |
| Need for fresh sample | Yes (within 24 h) | No |
| Need for diagnostic sample | No | Yes |
| Quantitative | Yes | Yes |
| Intrinsic quality control for hemodilution | Yes | No |
| Cell characterization | Yes | No |
| Molecular characterization | No | Yes |
| Availability | Wide | Limited |
| Reproducibility among centers | High | Not reported |
| Harmonization | Yes | Not reported |
| Cost | + | ++ |