FIGURE 5.

Overview of silvestrol‐mediated effects on MdMs and MdDCs. Effects of 5 nmol/L silvestrol during the differentiation of monocytes to MdMs and MdDCs, during the polarization of MdMs to M1 or M2 MdMs and during the activation of MdDCs are shown. Only changes of at least 20% are included in this overview. Predominantly pro‐inflammatory cytokines/chemokines are labelled in bright red, predominantly anti‐inflammatory cytokines/chemokines are shown in bright‐green and cytokines/chemokines with pro‐ and anti‐inflammatory potential are shown in bright blue. The direction of the arrows indicates a decrease (↓) or an increase (↑). For greater clarity, because the regulation of the surface marker was not as pronounced as the cytokine/chemokine alterations, the changes in the surface markers are shown as tendencies. Thus, a pink arrow indicates that the majority of the surface marker reflect a pro‐inflammatory phenotype, a green arrow demonstrates that the majority of the surface marker reflect anti‐inflammatory characteristics and both arrows indicate that the regulation tended towards equilibrium