Table 2.
List of in silico profiling targets for which at least 40 representatives of the CoV‐assessed molecules were predicted to be active “virtual hits”, sorted by this number of virtual hits as given in the first column.
|
#Hits |
Target ID |
Target description |
|---|---|---|
|
117 |
CHEMBL2581 |
Cathepsin D: Homo sapiens |
|
115 |
CHEMBL4801 |
Caspase‐1: Homo sapiens |
|
109 |
CHEMBL3776 |
Caspase‐8: Homo sapiens |
|
102 |
CHEMBL2334 |
Caspase‐3: Homo sapiens |
|
96 |
CHEMBL204 |
Thrombin: Homo sapiens |
|
90 |
CHEMBL3198 |
Acetylcholinesterase: Mus musculus |
|
64 |
CHEMBL5800 |
Falcipain 2: Plasmodium falciparum |
|
54 |
CHEMBL333 |
Matrix metalloproteinase‐2: Homo sapiens |
|
52 |
CHEMBL268 |
Cathepsin K: Homo sapiens |
|
51 |
CHEMBL3891 |
Calpain 1: Homo sapiens |
|
49 |
CHEMBL4026 |
Signal transducer and activator of transcription 3: Homo sapiens |
|
48 |
CHEMBL233 |
μ opioid receptor: Homo sapiens |
|
47 |
CHEMBL2039 |
Monoamine oxidase B: Homo sapiens |
|
46 |
CHEMBL325 |
Histone deacetylase 1: Homo sapiens |
|
46 |
CHEMBL321 |
Matrix metalloproteinase 9: Homo sapiens |
|
46 |
CHEMBL1741219 |
Short transient receptor potential channel 4: Mus musculus |
|
44 |
CHEMBL4662 |
Proteasome Macropain subunit MB1: Homo sapiens |
|
42 |
CHEMBL320 |
Muscarinic acetylcholine receptor M3: Rattus norvegicus |