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. 2020 May 27;11:1019. doi: 10.3389/fimmu.2020.01019

Figure 3.

Figure 3

Two days of bovine colostrum feeding has no impact on response to Staphylococcus epidermidis bacteremia. Results of Experiment 3 comparing preterm pigs infused with Staphylococcus epidermidis (SE) or saline (CON) at day 3, after being infused with maternal plasma and fed bovine colostrum (BC) or infant formula (IF) from after birth. (A) Body temperature 0–48 h post inoculation. (B) Motor activity, shown as the fraction of time with physical activity at 0–48 h post inoculation. (C) Neutrophil phagocytic rate 12–48 h post inoculation, defined as fraction of neutrophils with internalized bacteria. (D) Neutrophil phagocytic capacity 12–48 h post inoculation, defined as median fluorescent index of neutrophils with internalized bacteria. (E) T cells 12–48 h post inoculation, defined as fraction of CD3 positive lymphocytes. (F) CD4 cells 12–48 h post inoculation, defined as the CD4 positive, CD8 and FOXP3 negative fraction of T cells. (G) CD8 cells 12–48 h post inoculation, defined as the CD8 positive, CD4 and FOXP3 negative fraction of T cells. (H) Regulatory T cells 12–48 h post inoculation, defined as the FOXP3 and CD4 positive, CD8 negative fraction of T cells. CD4 positive as fraction (I) Plasma levels of bovine immunoglobulin G (IgG) at euthanasia. (A–I) Presented as means with corresponding standard errors. #: Effect of SE (p < 0.05), ##: Effect of SE (p < 0.01), ###: Effect of SE (p < 0.001), (*): Effect of diet (p ≤ 0.1 ≥ 0.05), *: Effect of diet (p < 0.05), **: Effect of diet (p < 0.01), ***: Effect of diet (p < 0.001).