Table 1.

Expression of IDO2, clinical-pathological parameters and other microenvironmental molecule associations.

Parameter	IDO2 low		IDO2 high			Total
	N	%	N	%	p	N	%
	31	16	160	84		191	100
GENDER
M	23	17	114	83	0.739	137	72
F	8	15	46	85		54	28
AGE
<68 years	13	15	74	85	0.659	87	46
≥68 years	18	17	86	83		104	54
SMOKING
Current smokers	13	17	64	83	0.910	77	40
Former smokers	16	16	82	84		98	51
Never smokers	2	12	14	88		16	9
RELAPSE
Yes	12	16	61	84	0.951	73	38
No	19	16	99	84		118	62
EXITUS
Yes	6	9	58	91	0.068	64	34
No	25	20	102	80		127	66
STAGE
Adcastage						122	64
I	6	8	68	92	0.964	74	61
II - III	4	8	44	92		48	39
Sqccbstage						69	36
I	7	26	20	74	0.513	27	39
II - III	14	33	28	67		42	61
HISTOTYPE
Adca	10	8	112	92	<0.001	122	64
Sqccb	21	30	48	70		69	36
Adca pattern						122	64
Other than solid	6	6	89	94	0.155	95	78
Solid	4	15	23	85		27	22
TILs DENSITY
Adca						122	64
Low	5	8	57	92	0.956	62	51
High	5	8	55	92		60	49
Sqccb						69	36
Low	12	34	23	66	0.480	35	51
High	9	26	25	74		34	49
TILs LOCALIZATION
Adca						122	64
Intratumoral	4	6	61	94	<0.001	65	53
Peritumoral	5	71	2	29		7	6
Mixed	4	9	42	91		46	38
Absent	0	0	4	100		4	3
Sqccb						69	36
Intratumoral	8	33	16	67	0.905	24	35
Peritumoral	2	29	5	71		7	10
Mixed	11	30	26	70		37	54
Absent	0	0	1	100		1	1
IDO1
Adca						122	64
Low	4	7	52	93	0.695	56	46
High	6	9	60	91		66	54
Sqccb						69	36
Low	10	32	21	68	0.766	31	45
High	11	29	27	71		38	55
PD-L1
Adca						122	64
Low	6	6	96	94	0.035	102	84
High	4	20	16	80		20	16
Sqccb						69	36
Low	19	40	29	60	0.012	48	70
High	2	10	19	90		21	30

^aAdc: adenocarcinoma.

^bSqcc: squamous cell carcinoma.