Table 2.

Fine and Gray model on overall survival (OS).

Parameter	Univariate analysis			Multivariate analysis
	SHRa	p-value	95% CIb	SHRa	p-value	95% CIb
IDO2
Low	ref	–	–	ref	–	–
High	2.64	0.028	(1.11–6.31)	2.94	0.011	(1.28–6.77)
IDO1
Low	ref	–	–	ref	–	–
High	1.71	0.041	(1.02–2.85)	1.64	0.041	(1.12–2.76)
SEX
Female	ref	–	–	ref	–	–
Male	2.03	0.029	(1.08–3.85)	2.22	0.019	(1.14–4.31)
STAGE
I	ref	–	–	ref	–	–
II–III	1.88	0.011	(1.16–3.07)	1.99	0.005	(1.23–3.24)
HISTOTYPE
Adcc	1.41	0.189	(0.84–2.37)	–
Sqccd	ref	–	–
AGE
<68 years	ref	–	–	–
≥68 years	1.04	0.887	(0.64–1.69)
SMOKING
Current smoker	1.86	0.219	(0.69–5.04)	–
Former smoker	1.60	0.350	(0.60–4.29)
Never smoker	ref	–	–
PD–L1
Low	1.04	0.904	(0.57–1.87)	–
High	ref	–	–
TILs DENSITY
Low	ref	–	–	–
High	1.05	0.841	(0.65–1.71)
TILs LOCALIZATION
Intratumoral	1.04	0.972	(0.12–9.19)	–
Peritumoral	1.45	0.752	(0.14–10.81)
Mixed	1.24	0.848	(0.14–10.81)
Absent	ref	–	–

^aSHR: Subdistribution Hazard Ratio.

^bCI: Confidence Interval.

^cAdc: adenocarcinoma.

^dSqcc: squamous cell carcinoma.